Prion protein and its interactions with metal ions (Cu2+, Zn2+, and Cd2+) and metallothionein 3
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چکیده
منابع مشابه
Prion protein and its interactions with metal ions (Cu, Zn, and Cd) and metallothionein 3
The effects of heavy metals (Zn 2+ , Cu 2+ , and/or Cd 2+ ) on Escherichia coli expressing either prion (hPrP C ) or metallothionein 3 (MT-3) brain proteins capable of binding these metals were investigated. The expression of hPrP C or MT-3 in E.coli was confirmed using western-blot and dot-blot methods. After analyzing growth curves, we found that bacteria expressing prion protein better toler...
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Zinc and Cu metabolism in crustacea changes dramatically during the molt cycle. Metallothionein (MT) and MT-like proteins are implicated in the handling of both metal ions as well as in the detoxification of Cd. Distribution of Cd2 / Cu / and Zn2 / in cytosol and among MT-like species has been determined. Lobsters were treated to induce MT as in mammals with dexamethasone (dex) or stress from t...
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چکیده ندارد.
Metallothionein Zn2+- and Cu2+-clusters from first-principles calculations.
Detailed electronic structures of Zn(II) and Cu(II) clusters from metallothioneins (MT) have been obtained using density functional theory (DFT), in order to investigate how oxidative stress-caused Cu(II) intermediates affect Zn-binding to MT and cooperatively lead to Cu(I)MT. The inferred accuracy is ∼0.02-0.03 Å for metal-thiolate bond lengths for the models that are the most realistic MT mod...
متن کاملExposure of human proximal tubule cells to cd2+, zn2+, and Cu2+ induces metallothionein protein accumulation but not metallothionein isoform 2 mRNA.
The organization of the human metallothionein (MT) gene family is more complex than the commonly used mouse and rat models. The human MTs are encoded by a family of genes consisting of 10 functional and 7 nonfunctional MT isoforms. One objective of this study was to determine if the accumulation of MT protein in cultures of human proximal tubule (HPT) cells exposed to metals is similar to that ...
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ژورنال
عنوان ژورنال: ADMET & DMPK
سال: 2015
ISSN: 1848-7718
DOI: 10.5599/admet.3.3.191